Team I Gene Prediction Group

Members: Maria Ahmad, Hira Anis, Jessica Mulligan, Priya Narayanan, Aaron Pfennig, Winnie Zheng

Introduction

Prokaryotic Gene Feature

• Prokaryotic genes have a relatively well-understood promoter sequence, such as a regulatory sequence, which can regulate the transcription of the gene into an mRNA.
• Each prokaryotic gene has open reading frames(ORF) which start with start codons and end with end codons with no interruptions(end-codons) in-between, so it can provide a good, but not assured prediction of the protein-coding regions.

Gene Prediction

Gene prediction or gene finding is a process of identifying the regions of genomic DNA that encode genes. It is devised two-classes of methods that use similarity-based(homology) searches and ab initio prediction to capture the compositional differences among coding regions which will be translated into protein and noncoding DNA which can be translated into tRNAs and rRNAs.